Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding
Author:
Affiliation:
1. Division of Structural Biology; The Institute of Cancer Research; London UK
2. Division of Cancer Biology; The Institute of Cancer Research; London UK
3. Division of Cancer Therapeutics; The Institute of Cancer Research; London UK
Funder
Wellcome Trust
Cancer Research UK
The Institute of Cancer Research (ICR)
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.14038/fullpdf
Reference162 articles.
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3. Tankyrase inhibition blocks Wnt/β-catenin pathway and reverts resistance to PI3K and AKT inhibitors in the treatment of colorectal cancer;Arques;Clin Cancer Res,2016
4. Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis;Bae;J Biol Chem,2002
5. PLOS ONE: inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells;Bao;PLoS One,2012
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