Affiliation:
1. Department of Biochemistry, Graduate School of Medicine Juntendo University Tokyo Japan
2. Institute of Microbial Chemistry Tokyo Japan
3. Department of Lipid Signaling National Center for Global Health and Medicine Tokyo Japan
Abstract
SummaryLeukotriene B4 (LTB4) was recognized as an arachidonate‐derived chemotactic factor for inflammatory cells and an important drug target even before the molecular identification of its receptors. We cloned the high‐ and low‐affinity LTB4 receptors, BLT1 and BLT2, respectively, and examined their functions by generating and studying gene‐targeted mice. BLT1 is involved in the pathogenesis of various inflammatory and immune diseases, including asthma, psoriasis, contact dermatitis, allergic conjunctivitis, age‐related macular degeneration, and immune complex‐mediated glomerulonephritis. Meanwhile, BLT2 is a high‐affinity receptor for 12‐hydroxyheptadecatrienoic acid, which is involved in the maintenance of dermal and intestinal barrier function, and the acceleration of skin and corneal wound healing. Thus, BLT1 antagonists and BLT2 agonists are promising candidates in the treatment of inflammatory diseases.
Funder
Japan Agency for Medical Research and Development
Ministry of Education, Culture, Sports, Science and Technology
Takeda Science Foundation
Subject
Immunology,Immunology and Allergy
Cited by
3 articles.
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