Affiliation:
1. Murdoch Children's Research Institute The Royal Children's Hospital Parkville Victoria Australia
2. Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences University of Melbourne Parkville Victoria Australia
3. The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute Parkville Victoria Australia
Abstract
SummaryLymphoid cells encompass the adaptive immune system, including T and B cells and Natural killer T cells (NKT), and innate immune cells (ILCs), including Natural Killer (NK) cells. During adult life, these lineages are thought to derive from the differentiation of long‐term hematopoietic stem cells (HSCs) residing in the bone marrow. However, during embryogenesis and fetal development, the ontogeny of lymphoid cells is both complex and multifaceted, with a large body of evidence suggesting that lymphoid lineages arise from progenitor cell populations antedating the emergence of HSCs. Recently, the application of single cell RNA‐sequencing technologies and pluripotent stem cell‐based developmental models has provided new insights into lymphoid ontogeny during embryogenesis. Indeed, PSC differentiation platforms have enabled de novo generation of lymphoid immune cells independently of HSCs, supporting conclusions drawn from the study of hematopoiesis in vivo. Here, we examine lymphoid development from non‐HSC progenitor cells and technological advances in the differentiation of human lymphoid cells from pluripotent stem cells for clinical translation.
Funder
National Health and Medical Research Council
Novo Nordisk Fonden
Subject
Immunology,Immunology and Allergy
Cited by
2 articles.
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