Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep

Author:

Gungor Huseyin1ORCID,Corum Orhan2ORCID,Durna Corum Duygu2ORCID,Kumru Alper Serhat1ORCID,Yilmaz Gökhan1ORCID,Coskun Devran3ORCID,Coskun Alparslan4ORCID,Uney Kamil5ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Sivas Cumhuriyet University Sivas Turkiye

2. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University Antakya Turkiye

3. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Siirt University Siirt Turkiye

4. Department of Internal Medicine, Faculty of Veterinary Medicine Sivas Cumhuriyet University Sivas Turkiye

5. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Selcuk University Konya Turkiye

Abstract

AbstractThe aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with a 15‐day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography‐ultraviolet, and pharmacokinetic parameters were evaluated by non‐compartmental analysis. Meloxicam was detected up to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose increased from 0.5 to 2 mg/kg, terminal elimination half‐life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1 mg/kg dose, it was determined that Vdss decreased and C0.083h increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of >0.39 μg/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses, respectively. These results show that meloxicam exhibits non‐linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of ≥1 mg/kg in sheep.

Publisher

Wiley

Subject

General Veterinary,Pharmacology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3