Inactivated antithombin as anticoagulant reversal in a rat model of cardiopulmonary bypass: a potent and potentially safer alternative to protamine-Reference-Cited by-同舟云学术

Inactivated antithombin as anticoagulant reversal in a rat model of cardiopulmonary bypass: a potent and potentially safer alternative to protamine

Published:2018-01-24 Issue:5 Volume:180 Page:715-720
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Bianchini Elsa P.¹,Sebestyen Alexandre²,Abache Toufik³,Bourti Yasmine¹,Fontayne Alexandre³,Richard Vincent⁴,Tamion Fabienne⁵,Plantier Jean-Luc³,Doguet Fabien²,Borgel Delphine¹⁶^ORCID

Affiliation:

1. INSERM; UMR-S1176; Univ. Paris-Sud; Université Paris-Saclay; Le Kremlin-Bicêtre France

2. Department of Thoracic and Cardiovascular Surgery; Inserm U1096; Normandie Univ; UNIROUEN; Rouen University Hospital; Rouen France

3. LFB Biotechnologies; Lille France

4. Department of Pharmacology; Inserm U1096; Normandie Univ; UNIROUEN; Rouen University Hospital; Rouen France

5. Department of Intensive Care; Inserm U1096; Normandie Univ; UNIROUEN; Rouen University Hospital; Rouen France

6. APHP; Laboratoire d'Hématologie; Hôpital Universitaire Necker-Enfants Malades; Paris France

Funder

Agence Nationale de la Recherche

Publisher

Wiley

Subject

Hematology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bjh.15091/fullpdf

Reference21 articles.

1. Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin;Ansell;Thrombosis Research,2016

2. Anti-protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis;Bakchoul;Blood,2013

3. Inhibition of factor IXa by the pegnivacogin system during cardiopulmonary bypass: a potential substitute for heparin. A study in baboons;Bel;European Journal of Cardio-Thoracic Surgery,2016

4. Development of a recombinant antithrombin variant as a potent antidote to fondaparinux and other heparin derivatives;Bianchini;Blood,2011

5. Inactivated antithrombins as fondaparinux antidotes: a promising alternative to haemostatic agents as assessed in vitro in a thrombin-generation assay;Bourti;Thrombosis and Haemostasis,2016

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