Affiliation:
1. Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou Zhejiang China
2. Key Laboratory of Kidney Disease Prevention and Control Technology Hangzhou Zhejiang China
3. Linping Hospital of Integrated Traditional Chinese and Western Medicine Hangzhou Zhejiang China
Abstract
AbstractIntroductionThis study was designed to investigate whether renal α‐klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD).MethodsWe conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And α‐klotho expressions were assessed by RT‐PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed.ResultsRenal α‐klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy.ConclusionsThe renal α‐klotho is related to renal pathology.
Funder
Natural Science Foundation of Zhejiang Province
Hangzhou Science and Technology Bureau
National Natural Science Foundation of China