Affiliation:
1. Mansoura Nephrology and Dialysis Unit Mansoura Faculty of Medicine Mansoura Egypt
2. Clinical Pathology Department Mansoura Faculty of Medicine Mansoura Egypt
Abstract
AbstractBackgroundChronic kidney disease (CKD) is associated with a state of chronic inflammation. This study aimed to investigate effects of Ramadan fasting on the markers of chronic inflammation and gut bacterial endotoxin levels in maintenance hemodialysis.MethodA prospective self‐controlled observational study included 45 patients. Serum levels of High Sensitive CRP (hsCRP), indoxyl sulfate, and trimethylamine‐n‐levels were measured within a week before and a week after Ramadan fasting.ResultsTwenty‐seven patients have fasted more than 15 days (29 ± 2.2 days). The levels of high sensitive C‐reactive protein (hsCRP) (median of 62 mg/L vs. 91 mg/L), trimethylamine‐n‐oxide (TMAO) (median of 4.5 μmoL/L vs. 17 μmoL/L), platelet‐to‐lymphocyte ratio (PLR) (mean of 98.9 mg/L vs. 111.8 mg/L) and neutrophil‐to‐lymphocyte ratio (NLR) (median of 1.56 vs. 1.59) were significantly lower after Ramadan fasting with p < 0.001, p < 0.001, p < 0.001, and p = 0.04, respectively.ConclusionA beneficial effect of Ramadan fasting on levels of bacterial endotoxins and markers of chronic inflammation in hemodialysis patients was observed.