Correlation between bradykinin concentration and blood pressure during <scp>Rheocarna</scp> therapy: <scp>A</scp> single‐center case series-Reference-Cited by-同舟云学术

Correlation between bradykinin concentration and blood pressure during Rheocarna therapy: A single‐center case series

Published:2024-01-03 Issue: Volume: Page:
ISSN:1744-9979
Container-title:Therapeutic Apheresis and Dialysis
language:en
Short-container-title:Ther Apher Dial

Author:

Handa Takaya¹^ORCID,Fujii Masaki²,Ando Masumi³,Masuda Mayumi³,Sokai Yuko²,Tsuji Yoshiki²,Fukuda Yui¹,Ohue Kaoru¹,Higashi Yoshiaki¹,Mori Keita P.¹,Endo Tomomi¹,Tsukamoto Tatsuo¹

Affiliation:

1. Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke‐Kofukai Osaka Japan

2. Department of Clinical Engineering Medical Research Institute Kitano Hospital, PIIF Tazuke‐Kofukai Osaka Japan

3. Department of the Blood Purification Center of Kitano Hospital Medical Research Institute Kitano Hospital, PIIF Tazuke‐Kofukai Osaka Japan

Abstract

AbstractIntroductionA novel LDL (low‐density lipoprotein) apheresis therapeutic option, Rheocarna, has garnered attention as an alternative therapy for chronic limb‐threating ischemia (CLTI). Bradykinin‐mediated vasodilation is involved in the effects of LDL apheresis and a decrease in blood pressure (BP), but the changes in bradykinin concentration during Rheocarna therapy are unknown.MethodsThe study involved patients with CLTI treated with Rheocarna at our hospital, from April 2022 to August 2023.ResultsAfter Rheocarna therapy, skin ulcers improved in 80% of the patients. Circuit coagulation was observed in two patients with high fibrinogen levels. A decrease in BP was observed at approximately the same time when the bradykinin concentration peaked. The peak bradykinin concentration in a patient undergoing hemodialysis at the same time was considerably lower than that in the other patients.ConclusionThis is the first report on the changes in bradykinin concentration under Rheocarna therapy.

Publisher

Wiley

Subject

Nephrology,Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/1744-9987.14105

Reference11 articles.

1. Review of the Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia

2. Three-Year Outcomes of Surgical Versus Endovascular Revascularization for Critical Limb Ischemia

3. Rheocarna^® as an alternative therapeutic option for patients with chronic limb-threatening ischemia: A case report

4. The influence of the obesity paradox and chronic kidney disease on long-term survival in a Japanese cohort with peripheral arterial disease

5. Mortality rates and walking ability transition after lower limb major amputation in hemodialysis patients