Retrospective observational study of changes in serum cytokines and adiponectin with continuous plasma exchange with dialysis therapy for severe COVID‐19

Author:

Suzuki Yuya1,Nakae Hajime1,Satoh Kasumi1,Hirasawa Nobuhisa1,Kameyama Komei1,Irie Yasuhito1,Kitamura Toshiharu1,Nara Tasuku1,Maeno Kyohei1,Yoshida Kenji1,Okuyama Manabu1

Affiliation:

1. Department of Emergency and Critical Care Medicine Akita University Graduate School of Medicine Akita Japan

Abstract

AbstractIntroductionCoronavirus disease 2019 (COVID‐19) is associated with a marked increase in the inflammatory cytokines, IL‐6 and IL‐18. Blood purification therapy aimed at controlling cytokines is one treatment option; however, evidence of its effectiveness is needed. Plasma exchange with dialysis (PED) is a blood purification method involving selective plasma exchange with dialysate flowing through the outer hollow fiber of the plasma separator. In this retrospective study, we investigated the efficacy of continuous PED (cPED) over 48 h in five patients with severe COVID‐19.MethodsWe assessed changes in IL‐6 and IL‐18, as well as adiponectin (APN).ResultsThere were no significant differences in changes in IL‐6 and IL‐18, but there was a marked improvement in cases with abnormally high IL‐6 and IL‐18 levels at baseline. APN, which inhibits inflammatory cytokines, was significantly elevated post‐cPED.ConclusionOur results suggest that cPED therapy is an effective treatment for COVID‐19.

Publisher

Wiley

Subject

Nephrology,Hematology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3