Affiliation:
1. Department of Cardiology Tokyo Bay Medical Center Urayasu Japan
2. Division of Vascular Surgery The Jikei University School of Medicine Tokyo Japan
3. Department of Nephrology, Endocrinology, and Diabetes Tokyo Bay Medical Center Urayasu Japan
Abstract
AbstractIntroductionLipoprotein apheresis (LA) is a possible adjunct treatment for no‐option chronic limb‐threatening ischemia (CLTI). This study aimed to assess the impact of a novel LA for no‐option CLTI.MethodsWe retrospectively assessed 19 patients with no‐option CLTI treated using the novel LA. The primary outcome was a change in the skin perfusion pressure (SPP) after treatment with LA, and the secondary outcomes were changes in the viscosity‐related laboratory parameters.ResultsThe wound‐healing rate was 68.4%. The SPP at 2–3 weeks after series of LA were significantly higher both in the dorsal (41 vs. 53 mmHg, p = 0.037) and plantar (50.0 vs. 61.0 mmHg, p = 0.018) sides, compared to those at baseline. The viscosity‐related laboratory markers were also significantly improved after the treatment; low‐density lipoprotein‐cholesterol (57.0 vs. 43.0 mg/dL, p = 0.002), fibrinogen (333 vs. 258 mg/dL, p < 0.001), and C‐reactive protein (0.99 vs. 0.42 mg/dL, p = 0.001).ConclusionThe novel LA significantly increased the SPP and improved relevant laboratory findings.
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