The effect of the time from diagnosis to induction therapy on prognosis in patients with acute leukemia undergoing leukapheresis for symptomatic hyperleukocytosis

Author:

Pınar İbrahim Ethem1ORCID,Özkocaman Vildan1,Ersal Tuba1,Dağtekin Mehmet Emin2,Yalçın Cumali1,Orhan Bedrettin1,Candar Ömer1,Çubukçu Sinem1,Güllü Koca Tuba1,Gürsoy Vildan3,Özkalemkaş Fahir1

Affiliation:

1. Department of Internal Medicine, Division of Hematology Bursa Uludag University Faculty of Medicine Bursa Turkey

2. Department of Internal Medicine Bursa Uludag University Faculty of Medicine Bursa Turkey

3. Department of Internal Medicine, Division of Hematology Bursa City Hospital Bursa Turkey

Abstract

AbstractIntroductionOur study investigated leukapheresis's effect on delayed induction therapy outcomes in patients with acute leukemia presenting with symptomatic hyperleukocytosis.MethodsThis retrospective cohort study included 30 adult patients diagnosed with acute leukemia who underwent leukapheresis for leukostasis. The patients were divided into the first 24 h and >24 h groups, according to the time from diagnosis to induction therapy (TDT).ResultsThere was no significant difference between the TDT groups regarding complete remission (CR), 4‐week mortality, and overall survival (OS) at a median follow‐up of 409 days. Tumor lysis syndrome, disseminated intravascular coagulation, and hemoglobin levels were significant in early mortality. In univariate analysis, age, hemoglobin levels, patients' eligibility for intensive chemotherapy, and achieving CR were critical factors for OS.ConclusionThe study findings suggest that waiting for the clinical and laboratory results may be a safe and reasonable approach before assigning patients the best treatment option with leukapheresis.

Publisher

Wiley

Subject

Nephrology,Hematology

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