Association between serum sodium and 28‐day mortality in sepsis patients: A secondary data analysis from three large critical illness cohorts

Abstract

AbstractObjectiveThe present study was designed to explore the association between serum sodium and mortality in patients with sepsis by using a large sample, multicenter MIMIC‐IV database.MethodsWe extracted the data of 34 925 sepsis patients from the retrospective cohort mimicIV database. After adjusting the confounders, we explored the independent effects of serum sodium on 28‐day mortality.ResultsA nonlinear relationship existed between serum sodium and 28‐day mortality, of which a negative association was found between serum sodium and 28‐day mortality (odds ratio: 0.95, 95% CI: 0.94, 0.96, p = 0.0001) when serum sodium was in 102 mmol/L to 138 mmol/L, but a positive correlation appeared when sodium climbed to the range of 140–179 mmol/L (odds ratio: 1.04, 95% CI: 1.03–1.06, p = 0.0001).ConclusionsBoth lower and higher serum sodium levels are associated with an increased risk of death in sepsis patients.