Spinal astroblastoma, MN1 altered in 3‐year‐old child: An uncommon tumor at an unusual site

Author:

Panda Arun Kumar1ORCID,Das Sumanta2ORCID,Singh Anuj3,Vaishya Sandeep4,Gupta Rakesh Kumar5,Sharma Mehar Chand2ORCID,Ahlawat Sunita1

Affiliation:

1. Department of Pathology, Agilus Diagnostics Ltd‐Fortis Memorial Research Institute (FMRI) Gurugram India

2. Neuropathology Laboratory All India Institute of Medical Sciences New Delhi India

3. Department of Pediatric Oncology Fortis Memorial and Research Hospital Gurugram India

4. Department of Neurosurgery Fortis Memorial and Research Hospital Gurugram India

5. Department of Radiodiagnosis Fortis Memorial and Research Hospital Gurugram India

Abstract

Astroblastoma is an uncommon circumscribed glial tumor mostly involving the cerebral hemisphere. The characteristic molecular alteration is meningioma (disrupted in balanced translocation) 1 (MN1) rearrangement. No definite World Health Organization grade has been assigned as both low‐ and high‐grade tumors are known to occur. Tumors in the spine are extremely rare; to date only three cases have been reported in the literature. A vigilant microscopy and ancillary testing aid in diagnosis when the tumors present in unusual locations, as in our case. The prompt differentiation of this tumor from its mimickers is a mandate as modalities of management are different and not clearly established.

Publisher

Wiley

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