Prednisolone improves hippocampal regeneration after trimethyltin‐induced neurodegeneration in association with prevention of T lymphocyte infiltration

Author:

Sakurai Masashi1ORCID,Takenaka Miki1,Mitsui Yuki1,Sakai Yusuke2,Morimoto Masahiro1

Affiliation:

1. Department of Veterinary Pathology, Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi Japan

2. Department of Pathology National Institute of Infectious Diseases Tokyo Japan

Abstract

The endogenous regenerative capacity of the brain is quite weak; however, a regenerative reaction, the production of new neurons (neurogenesis), has been reported to occur in brain lesions. In addition, leukocytes are well known to infiltrate brain lesions. Therefore, leukocytes would also have a link with regenerative neurogenesis; however, their role has not been fully elucidated. In this study, we investigated leukocyte infiltration and its influence on brain tissue regeneration in a trimethyltin (TMT)‐injected mouse model of hippocampal regeneration. Immunohistochemically, CD3‐positive T lymphocytes were found in the hippocampal lesion of TMT‐injected mice. Prednisolone (PSL) treatment inhibited T lymphocyte infiltration and increased neuronal nuclei (NeuN)‐positive mature neurons and doublecortin (DCX)‐positive immature neurons in the hippocampus. Investigation of bromodeoxyuridine (BrdU)‐labeled newborn cells revealed the percentage of BrdU/NeuN‐ and BrdU/DCX‐positive cells increased by PSL treatment. These results indicate that infiltrated T lymphocytes prevent brain tissue regeneration by inhibiting hippocampal neurogenesis.

Publisher

Wiley

Subject

Neurology (clinical),General Medicine,Pathology and Forensic Medicine

Reference51 articles.

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