Kidney Transplant Recipients Carrying theCYP3A4*22Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations

Author:

Pallet N.1234,Jannot A.-S.345,El Bahri M.1,Etienne I.6,Buchler M.7,de Ligny B. H.8,Choukroun G.9,Colosio C.10,Thierry A.11,Vigneau C.12,Moulin B.13,Le Meur Y.14,Heng A.-E.15,Subra J.-F.16,Legendre C.17,Beaune P.134,Alberti C.18,Loriot M. A.134,Thervet E.234

Affiliation:

1. Clinical Chemistry; Hôpital Européen Georges Pompidou; Assistance Publique Hôpitaux de Paris; Paris France

2. Department of Nephrology; Hôpital Européen Georges Pompidou; Assistance Publique Hôpitaux de Paris; Paris France

3. Paris Descartes University; Paris France

4. Sorbonne Paris Cité; INSERM UMRS; 1147 Paris France

5. Department of Medical Informatics and Public Health; Hôpital Européen Georges Pompidou; Assistance Publique Hôpitaux de Paris; Paris France

6. Department of Nephrology; CHU Rouen; Rouen France

7. Department of Nephrology; CHU Tours; Tours France

8. Department of Nephrology; CHU Caen; Caen France

9. Department of Nephrology; CHU Amiens; Amiens France

10. Department of Nephrology; CHU Reims; Reims France

11. Department of Nephrology; CHU Poitiers; Poitiers France

12. Department of Nephrology; CHU Rennes; Rennes France

13. Department of Nephrology; CHU Strasbourg; Strasbourg France

14. Department of Nephrology; CHU Brest; Brest France

15. Department of Nephrology; CHU Clermont-Ferrand; Clermont-Ferrand France

16. Department of Nephrology; CHU Angers; Angers France

17. Department of Nephrology; Necker Hospital; Assistance Publique Hôpitaux de Paris; Paris France

18. Clinical Investigation Center; Assistance Publique-Hôpitaux de Paris; Hôpital Robert Debré; Paris France

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference16 articles.

1. Pharmacogenetics in kidney transplantation: Recent updates and potential clinical applications;Elens;Mol Diagn Ther,2012

2. The pharmacogenetics of calcineurin inhibitor-related nephrotoxicity;Hesselink;Ther Drug Monit,2010

3. Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus;Kamdem;Clin Chem,2005

4. Metabolism of the immunosuppressant tacrolimus in the small intestine: Cytochrome P450, drug interactions, and interindividual variability;Lampen;Drug Metab Dispos,1995

5. Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II;Staatz;Clin Pharmacokinet,2010

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