Histopathological risk assessment in multisite epithelial dysplasia: A meta‐analysis-Reference-Cited by-同舟云学术

Histopathological risk assessment in multisite epithelial dysplasia: A meta‐analysis

Published:2024-06-30 Issue: Volume: Page:
ISSN:1354-523X
Container-title:Oral Diseases
language:en
Short-container-title:Oral Diseases

Author:

Ferraz Daniel Lobato Ferreira¹^ORCID,dos Santos Erison Santana¹^ORCID,Pedroso Caique Mariano¹^ORCID,Silva Brunno Santos de Freitas²^ORCID,Kujan Omar³^ORCID,Salo Tuula Anneli⁴⁵⁶⁷⁸^ORCID,Malki Mohammed I.⁹^ORCID,Juteau Susanna¹⁰^ORCID,Vargas Pablo Agustin¹^ORCID,Lopes Marcio Ajudarte¹^ORCID,Santos‐Silva Alan Roger¹^ORCID

Affiliation:

1. Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba São Paulo Brazil

2. Department of Stomatologic Sciences, School of Dentistry Federal University of Goiás Goiânia Goiás Brazil

3. UWA Dental School The University of Western Australia Nedlands Western Australia Australia

4. Oral Medicine and Pathology, Research Unit of Population Health University of Oulu Oulu Finland

5. Medical Research Center and Oulu University Hospital Oulu Finland

6. Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland

7. Translational Immunology Research Program (TRIMM) and iCAN Digital Precision Cancer Medicine Flagship University of Helsinki Helsinki Finland

8. Department of Pathology Helsinki University Hospital Helsinki Finland

9. Pathology Unit, Department of Basic Medical Sciences, College of Medicine QU Health, Qatar University Doha Qatar

10. Department of Pathology, Haartman Institute University of Helsinki and HUSLAB Helsinki Finland

Abstract

AbstractObjectiveHistopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.MethodsThe review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.ResultsForty‐six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta‐analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.ConclusionsNo significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/odi.15052

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