Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study

Author:

Angelo H. D.12,Gomes Silva I. I. F.3,Oliveira R. D. R.4,Louzada-Júnior P.4,Donadi E. A.4,Crovella S.5,Maia M. M. D.6,de Souza P. R. E.6,Sandrin-Garcia P.2

Affiliation:

1. Department of General Formation; Federal Institute of Pernambuco; Garanhuns Pernambuco Brazil

2. Postgraduate Program in Genetics; Federal University of Pernambuco; Recife Pernambuco Brazil

3. Postgraduate Program in Applied Molecular and Cellular Biology; University of Pernambuco (ICB/UPE); Recife Pernambuco Brazil

4. Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto; University of São Paulo; Ribeirão Preto São Paulo Brazil

5. Department of Genetics; Federal University of Pernambuco; Recife Pernambuco Brazil

6. Department of Biology; Federal Rural University of Pernambuco; Recife Pernambuco Brazil

Funder

Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado do Estado de São Paulo

Publisher

Wiley

Subject

Genetics,Biochemistry,Immunology,General Medicine,Immunology and Allergy

Reference20 articles.

1. Rheumatoid arthritis. Pathophysiology and implications for therapy;Harris;N Engl J Med,1990

2. Gender differences in autoimmune diseases illustrated by rheumatoid arthritis;Danneskiold-Samsøe;Ugeskr Laeger,2007

3. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family;Dinarello;J Allergy Clin Immunol,1999

4. Interleukin-18 can promote synovial inflammation through activation of peripheral blood and synovial neutrophils;Leung;Arthritis Rheum,2000

5. Interleukin-18 gene polymorphism, but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis;Lee;Immunogenetics,2007

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