Zafirlukast is a broad‐spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times

Author:

Holbrook Lisa‐Marie12,Keeton Shirley J.1,Sasikumar Parvathy13,Nock Sophie1,Gelzinis Justine4,Brunt Elizabeth14,Ryan Sarah1,Pantos Megan M.4,Verbetsky Christina A.4,Gibbins Jonathan M.1,Kennedy Daniel R.4

Affiliation:

1. Institute for Cardiovascular and Metabolic Research, School of Biological Sciences University of Reading Reading UK

2. School of Cardiovascular Medicine and Sciences King's College London London UK

3. Centre for Haematology Imperial College London London UK

4. College of Pharmacy and Health Sciences Western New England University Springfield Massachusetts USA

Funder

British Heart Foundation

Medical Research Council Canada

Publisher

Wiley

Subject

Pharmacology

Reference56 articles.

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2. Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

3. A substrate-driven allosteric switch that enhances PDI catalytic activity

4. Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

5. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice;Cho J.;The Journal of Clinical Investigation,2008

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