Discovery and evaluation of biphenyl derivatives of 2‐iminobenzimidazoles as prototype dual <scp>PTP1B</scp> inhibitors and <scp>AMPK</scp> activators with in vivo antidiabetic activity-Reference-Cited by-同舟云学术

Discovery and evaluation of biphenyl derivatives of 2‐iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity

Published:2023-01-29 Issue:4 Volume:101 Page:896-914
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Babkov Denis A.¹²,Zhukovskaya Olga N.³,Brigadirova Anastasia A.¹,Prilepskaya Diana R.¹,Kolodina Alexandra A.³,Abbas Abbas Haider S.³^ORCID,Morkovnik Anatolii S.³,Sobhia M. Elizabeth⁴,Ghosh Ketan⁴,Spasov Alexander A.¹

Affiliation:

1. Department of Pharmacology & Bioinformatics Volgograd State Medical University Volgograd Russia

2. Scientific Center for Innovative Drugs Volgograd State Medical University Volgograd Russia

3. Institute of Physical and Organic Chemistry Southern Federal University Rostov‐on‐Don Russia

4. Department of Pharmacoinformatics National Institute of Pharmaceutical Education and Research (NIPER) SAS Nagar India

Funder

Ministry of Education and Science of the Russian Federation

Russian Science Foundation

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14198

Reference51 articles.

1. Imidazo[1,2-a]benzimidazole derivatives: XXVIII. Syntheses and heterocyclizations on the basis of 1-allyl-2-aminobenzimidazole

2. Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators

3. Identification of novel PTP1B inhibitors by pharmacophore based virtual screening, scaffold hopping and docking

4. Synthesis, biological evaluation, and molecular docking study of some new rohitukine analogs as protein tyrosine phosphatase 1B inhibitors