Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study-Reference-Cited by-同舟云学术

Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study

Published:2023-05-24 Issue:8 Volume:77 Page:449-456
ISSN:1323-1316
Container-title:Psychiatry and Clinical Neurosciences
language:en
Short-container-title:Psychiatry Clin Neurosci

Author:

Oh Dae Jong¹,Bae Jong Bin²,Lipnicki Darren M.³,Han Ji Won²⁴,Sachdev Perminder S.³⁵^ORCID,Kim Tae Hui⁶,Kwak Kyung Phil⁷,Kim Bong Jo⁸,Kim Shin Gyeom⁹,Kim Jeong Lan¹⁰,Moon Seok Woo¹¹,Park Joon Hyuk¹²,Ryu Seung‐Ho¹³,Youn Jong Chul¹⁴,Lee Dong Young²¹⁵^ORCID,Lee Dong Woo¹⁶,Lee Seok Bum¹⁷,Lee Jung Jae¹⁷,Jhoo Jin Hyeong¹⁸,Skoog Ingmar¹⁹²⁰,Najar Jenna¹⁹²⁰,Sterner Therese R.¹⁹,Guaita Antonio²¹,Vaccaro Roberta²¹,Rolandi Elena²¹,Scarmeas Nikolaos²²²³,Yannakoulia Mary²⁴^ORCID,Kosmidis Mary H.²⁵,Riedel‐Heller Steffi G.²⁶,Roehr Susanne²⁶²⁷,Dominguez Jacqueline²⁸²⁹,De Guzman Ma Fe²⁹,Fowler Krizelle Cleo²⁹,Lobo Antonio³⁰,Saz Pedro³⁰,Lopez‐Anton Raul³¹,Anstey Kaarin J.³²³³³⁴,Cherbuin Nicolas³³,Mortby Moyra E.³²³⁴,Brodaty Henry³,Trollor Julian³³⁵,Kochan Nicole³,Kim Ki Woong²⁴³⁶^ORCID,

Affiliation:

1. Workplace Mental Health Institute, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul South Korea

2. Department of Psychiatry Seoul National University, College of Medicine Seoul South Korea

3. Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health University of New South Wales Sydney New South Wales Australia

4. Department of Neuropsychiatry Seoul National University Bundang Hospital Seongnam South Korea

5. Dementia Collaborative Research Centre University of New South Wales Sydney New South Wales Australia

6. Department of Psychiatry Yonsei University Wonju Severance Christian Hospital Wonju South Korea

7. Department of Psychiatry Dongguk University Gyeongju Hospital Gyeongju South Korea

8. Department of Psychiatry Gyeongsang National University, School of Medicine Jinju South Korea

9. Department of Neuropsychiatry Soonchunhyang University Bucheon Hospital Bucheon South Korea

10. Department of Psychiatry, School of Medicine Chungnam National University Daejeon South Korea

11. Department of Psychiatry, School of Medicine Konkuk University and Konkuk University Chungju Hospital Chungju South Korea

12. Department of Neuropsychiatry Jeju National University Hospital Jeju South Korea

13. Department of Psychiatry, School of Medicine Konkuk University and Konkuk University Medical Center Seoul South Korea

14. Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly Yongin South Korea

15. Department of Neuropsychiatry Seoul National University Hospital Seoul South Korea

16. Department of Neuropsychiatry Inje University Sanggye Paik Hospital Seoul South Korea

17. Department of Psychiatry Dankook University Hospital Cheonan South Korea

18. Department of Neuropsychiatry Kangwon National University Hospital Chuncheon South Korea

19. Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) University of Gothenburg Mölndal Sweden

20. Region Västra Götaland Sahlgrenska University Hospital Psychiatry, Cognition and Old Age Psychiatry Clinic Gothenburg Sweden

21. Golgi Cenci Foundation Abbiategrasso Italy

22. Department of Neurology, Aiginition Hospital National and Kapodistrian University of Athens Athens Greece

23. Department of Neurology Columbia University New York New York USA

24. Department of Nutrition and Dietetics Harokopio University Athens Greece

25. Lab of Cognitive Neuroscience, School of Psychology Aristotle University of Thessaloniki Thessaloniki Greece

26. Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty University of Leipzig Leipzig Germany

27. Global Brain Health Institute (GBHI), Trinity College Dublin Dublin Ireland

28. Institute for Neurosciences, St. Luke's Medical Center Quezon City Philippines

29. Institute for Dementia Care Asia Quezon City Philippines

30. Department of Medicine and Psychiatry Zaragoza University Aragon Spain

31. Departamento de Psicología y Sociología Universidad de Zaragoza Aragon Spain

32. School of Psychology University of New South Wales Sydney New South Wales Australia

33. Centre for Mental Health Research Australian National University Canberra Canberra Australia

34. Neuroscience Australia Sydney New South Wales Australia

35. Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine & Health University of New South Wales Sydney New South Wales Australia

36. Department of Brain and Cognitive Science Seoul National University College of Natural Sciences Seoul South Korea

Abstract

BackgroundParental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring.MethodsFor this cross‐sectional study, we harmonized and pooled data for 17,194 older adults from nine population‐based cohorts of eight countries. These studies conducted face‐to‐face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring.ResultsThe mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15–1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31–2.26), but not with the risk of non‐AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15–1.97) and AD (OR = 1.80, 95% CI = 1.33–2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28–3.55 in males; OR = 1.68, 95% CI = 1.16–2.44 for females).ConclusionsMaternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials.

Funder

Alzheimer's Association

Alzheimerfonden

European Regional Development Fund

Forskningsrådet om Hälsa, Arbetsliv och Välfärd

Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg

Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse

Ministry of Health and Welfare

National Health and Medical Research Council

National Institute on Aging

Philippine Council for Health Research and Development

Wellcome Trust