Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia
Author:
Affiliation:
1. Clinical Pharmacology Unit; Department of Human Metabolism; University of Sheffield; Sheffield; S10 2RX
2. Clinical Trials Service Unit; Oxford
3. Haematology Department; The Children's Hospital; Sheffield; UK
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12066/fullpdf
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3. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity;Weinshilboum;Am J Hum Genet,1980
4. Pharmacokinetics and pharmacodynamics of oral methotrexate and mercaptopurine in children with lower risk acute lymphoblastic leukaemia: a joint Children's Cancer Group and Pediatric Oncology Branch study;Balis FM Holcenberg;Blood,1998
5. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism;Lennard;Clin Pharmacol Ther,1989
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