Spreading Depression Enhances Human Neocortical Excitability in vitro-Reference-Cited by-同舟云学术

Spreading Depression Enhances Human Neocortical Excitability in vitro

Published:2008-05 Issue:5 Volume:28 Page:558-562
ISSN:0333-1024
Container-title:Cephalalgia
language:en
Short-container-title:Cephalalgia

Author:

Berger M¹,Speckmann E-J¹²,Pape HC¹²,Gorji A¹

Affiliation:

1. Institut für Physiologie I, Westfalische Wilhelms-Universitat Munster, Münster, Germany

2. Institut für Experimentelle Epilepsieforschung, Westfalische Wilhelms-Universitat Munster, Münster, Germany

Abstract

Cortical spreading depression (CSD) plays a role in migraine with aura. However, studies of the neuronal effects of CSD in human cortex are scarce. Therefore, in the present study, the effects of CSD on the field excitatory postsynaptic potentials (fEPSP) and the induction of long-term potentiation (LTP) were investigated in human neocortical slices obtained during epilepsy surgery. CSD significantly enhanced the amplitude of fEPSP following a transient suppressive period and increased the induction of LTP in the third layer of neocortical tissues. These results indicate that CSD facilitates synaptic excitability and efficacy in human neocortical tissues, which can be assumed to contribute to hyperexcitability of neocortical tissues in patients suffering from migraine.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1111/j.1468-2982.2008.01556.x

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