Pharmacologic study (JP28927) of alectinib in Japanese patients with ALK+ non-small-cell lung cancer with or without prior crizotinib therapy

Author:

Hida Toyoaki1,Nakagawa Kazuhiko2,Seto Takashi3,Satouchi Miyako4,Nishio Makoto5,Hotta Katsuyuki6,Takahashi Toshiaki7,Ohe Yuichiro89,Takeda Koji10,Tatsuno Masahiro11,Asakawa Takashi12,Shimada Tadashi12,Tanaka Tomohiro12,Tamura Tomohide813

Affiliation:

1. Department of Thoracic Oncology; Aichi Cancer Center; Nagoya Japan

2. Department of Medical Oncology; Kindai University Faculty of Medicine; Osaka Japan

3. Department of Thoracic Oncology; National Kyusyu Cancer Center; Fukuoka Japan

4. Department of Thoracic Oncology; Hyogo Cancer Center; Akashi Japan

5. Department of Thoracic Medical Oncology; The Cancer Institute Hospital of Japanese Foundation for Cancer Research; Tokyo Japan

6. Department of Allergy and Respiratory Medicine; Okayama University Hospital; Okayama Japan

7. Department of Thoracic Oncology; Shizuoka Cancer Center; Shizuoka Japan

8. Department of Thoracic Oncology; National Cancer Center Hospital; Tokyo Japan

9. National Cancer Center East; Chiba Japan

10. Department of Medical Oncology; Osaka City General Hospital; Osaka Japan

11. Translational Clinical Research Science & Strategy Department; Chugai Pharmaceutical Co. Ltd.; Tokyo Japan

12. Clinical Science & Strategy Department; Chugai Pharmaceutical Co. Ltd.; Tokyo Japan

13. Thoracic Center; St. Luke's International Hospital; Tokyo Japan

Funder

Chugai Pharmaceutical Co. Ltd.

Pfizer

Novartis

Novartis Pharma

Astellas Pharma

AstraZeneca

Ono Pharmaceutical

Bristol-Myers Squibb

Eli Lilly Japan

Taiho Pharmaceutical

Meso Scale Diagnostics

Takeda Pharmaceutical Company

Daiichi Sankyo Company

Quintiles

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference20 articles.

1. Ferlay J Soerjomataram I Ervik M et al GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 Lyon, France International Agency for Research on Cancer 2013 http://globocan.iarc.fr

2. Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors;Chia;Clin Epidemol,2014

3. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-hodgkin's lymphoma;Morris;Science,1994

4. Mechanistic insight into the ALK receptor tyrosine kinase in human cancer biology;Hallberg;Nat Cancer Rev,2013

5. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer;Soda;Nature,2007

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