Sarcoidosis in pregnancy

Author:

Odendaal Joshua12ORCID,Mackie Fiona L3,Tosounidou Sofia4,Ghosh Swati5,Knox Ellen6

Affiliation:

1. NIHR Clinical Lecturer, Division of Biomedical Sciences, Clinical Sciences Research Laboratories, Warwick Medical School University of Warwick Coventry CV2 2DX UK

2. Specialty Registrar in Obstetrics & Gynaecology University Hospitals Coventry & Warwickshire Coventry CV2 2DX UK

3. Subspecialty Trainee in Maternal Fetal Medicine Birmingham Women's and Children's NHS Foundation Trust Mindelsohn Way Birmingham B15 2TG UK

4. Consultant Rheumatologist University Hospitals Birmingham Mindelsohn Way Birmingham B15 2GW UK

5. Consultant Obstetrician Worcestershire Acute Hospitals NHS Trust Charles Hastings Way Worcester WR5 1DD UK

6. Consultant Obstetrician & Subspecialist in Maternal Medicine Birmingham Women's and Children's NHS Foundation Trust Mindelsohn Way Birmingham B15 2TG UK

Abstract

Key content: Sarcoidosis is an uncommon multi‐system disorder characterised by the presence of non‐caseating granulomas. It has a peak incidence between the ages of 20–40 years old. The pathogenesis of sarcoidosis is uncertain; however, it is known to be associated with an exaggerated T helper 1 (TH1) immune response leading to systemic inflammation and granuloma formation. Suppression in TH1 responses in pregnancy leads to disease remission in the majority of pregnancies. Nevertheless, the potential for decompensation in a subgroup remains, and consideration should be given to the pre‐pregnancy state. Sarcoidosis is associated with increased risk of maternal‐fetal morbidity, including growth restriction and pre‐eclampsia. Clinical management should focus on medication optimisation and mitigation of this increased risk. Learning objectives: To understand the clinical features, pathogenesis and diagnosis of sarcoidosis. To understand the effect of pregnancy on sarcoidosis. To understand the effect of sarcoidosis on pregnancy and the related obstetric outcomes. To understand the management of sarcoidosis in pregnancy. Ethical issues: There can be difficulties in appropriate management of medical disorders, such as sarcoidosis, with a limited obstetric evidence base. There are challenges in decision‐making regarding continuation of pregnancy in severe disease with an uncertain evidence base.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3