Peri‐operative and long‐term outcomes of kidney transplantation in patients with cystic fibrosis

Abstract

AbstractIntroductionThere is a lack of data regarding the peri‐operative and long‐term outcomes of kidney transplantation in cystic fibrosis (CF) patients. Herein, we report the peri‐operative and long‐term outcomes of kidney transplantation in CF patients.Materials and methodsAll CF patients who received a kidney transplant at the national kidney transplant center between 1993 and 2022 were identified. Recipients of the contralateral donor kidney were selected as a control group. Primary outcomes included 1‐, 5‐, and 10‐ year death‐censored graft survival and overall survival. Secondary outcomes included peri‐operative morbidity, acute graft rejection, delayed graft function (DGF), and length of stay (LOS).ResultsFourteen patients received a kidney transplant over the study period. Median age at transplantation was 35 (IQR 31, 40) years. The 1‐, 5‐, and 10‐year death‐censored graft survival was 92, 74, and 74% in the CF group compared to 100, 92, and 92% in the control group (p = .44). The 1‐, 5‐, and 10‐year overall survival in the CF group was 85, 66, and 57% compared to 100, 92, and 82% in the control group (p = .036). There was no significant difference in peri‐operative outcomes including LOS (10 vs. 11 days, p = .84), ICU admission (1 vs. 0 patients, p > .99), acute rejection episodes (2 vs. 1 patients, p > .99), and DGF (1 vs. 2 patients, p = .60).ConclusionCF patients have good long‐term graft survival, however, overall survival was worse compared to a matched cohort. These data provide important information for transplant surgeons when considering suitable donor allografts in this unique patient population.