Acquisition of chromosome 1q duplication in parental and genome‐edited human‐induced pluripotent stem cell‐derived neural stem cells results in their higher proliferation rate in vitro and in vivo

Author:

Mehrjardi Narges Zare12,Molcanyi Marek1,Hatay Firuze Fulya1,Timmer Marco3,Shahbazi Ebrahim2,Ackermann Justus P.4,Herms Stefan56,Heilmann‐Heimbach Stefanie5,Wunderlich Thomas F.478,Prochnow Nora9,Haghikia Aiden9,Lampert Angelika10,Hescheler Jürgen1,Neugebauer Edmund A. M.11,Baharvand Hossein212,Šarić Tomo1ORCID

Affiliation:

1. Center for Physiology and Pathophysiology Institute for Neurophysiology Medical Faculty University of Cologne Cologne Germany

2. Department of Stem Cells and Developmental Biology Cell Science Research Center Royan Institute for Stem Cell Biology and TechnologyACECR Tehran Iran

3. Department of Neurosurgery University Hospital Cologne Cologne Germany

4. Center for Molecular Medicine Cologne University of Cologne Cologne Germany

5. Department of Genomics, Life & Brain Center Institute for Human Genetics University of Bonn Bonn Germany

6. Department of Biomedicine Medical Genetics Research Group Genomics University Hospital Basel Basel Switzerland

7. Max Planck Institute for Metabolism Research and Institute for Genetics, University of Cologne Cologne Germany

8. Cologne Cluster of Excellence in Cellular Stress Responses in Aging‐Associated Diseases (CECAD) Cologne Germany

9. Clinic for Neurology St. Josef‐Hospital Clinic of the Ruhr‐University Bochum Bochum Germany

10. Institute of Physiology Uniklinik, RWTH Aachen University Aachen Germany

11. Medizinische Hochschule Brandenburg Theodor Fontane, Campus Neuruppin Neuruppin Germany

12. Department of Developmental Biology University of Science and Culture Tehran Iran

Funder

Deutsche Forschungsgemeinschaft

Royan Institute

Publisher

Wiley

Subject

Cell Biology,General Medicine

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