2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction

Author:

Cheng Hao-Wei1,Chein Rong-Jie2,Cheng Ting-Jen3,Wu Pei-Shan4,Wu Hsin-Yi2,Hung Pei-Fang5,Wang Chia-Jen6,Hsu Yuan-Ling7,Wong Jau-Min18,Yuan Ang89,Wong Chi-Huey3,Yang Pan-Chyr58,Pan Szu-Hua4710ORCID

Affiliation:

1. Institute of Biomedical Engineering; National Taiwan University; Taipei Taiwan

2. Institute of Chemistry; Academia Sinica; Taipei Taiwan

3. Genomics Research Center; Academia Sinica; Taipei Taiwan

4. Genome and Systems Biology Degree Program; National Taiwan University and Academia Sinica; Taipei Taiwan

5. Institute of Biomedical Sciences; Academia Sinica; Taipei Taiwan

6. Institute of Stem Cell and Translational Cancer Research; Chang Gung Memorial Hospital; Taoyuan Taiwan

7. Graduate Institute of Medical Genomics and Proteomics; National Taiwan University; Taipei Taiwan

8. Department of Internal Medicine; National Taiwan University Hospital; Taipei Taiwan

9. Department of Emergency Medicine; National Taiwan University Hospital; Taipei Taiwan

10. Doctoral Degree Program of Translational Medicine; National Taiwan University; Taipei Taiwan

Funder

National Taiwan University

Academia Sinica

Ministry of Science and Technology

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference44 articles.

1. Cancer statistics, 2017;Siegel;CA Cancer J Clin,2017

2. Global cancer statistics, 2012;Torre;CA Cancer J Clin,2015

3. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors;Jia;Nature,2016

4. Tumor suppressive functions of p53;Zilfou;Cold Spring Harb Perspect Biol,2009

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