Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agentFrancisella tularensis

Author:

Shaw Gary X.1,Li Yue2,Shi Genbin1,Wu Yan2,Cherry Scott1,Needle Danielle1,Zhang Di1,Tropea Joseph E.1,Waugh David S.1,Yan Honggao2,Ji Xinhua1

Affiliation:

1. Macromolecular Crystallography Laboratory; National Cancer Institute; Frederick MD USA

2. Department of Biochemistry and Molecular Biology; Michigan State University; East Lansing MI USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference56 articles.

1. The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery;Bermingham;BioEssays,2002

2. Where will new antibiotics come from?;Walsh;Nat Rev Microbiol,2003

3. Inhibition of folate biosynthesis and function as a basis for chemotherapy;Hitchings;Adv Enzymol Relat Areas Mol Biol,1965

4. Diaminopyrimidines

5. Sulfonamides

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