Affiliation:
1. Department of Surgery Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Abstract
AbstractAimRecent advances in treatment modalities have been made, limiting the indication of hepatic resection in the treatment strategy for hepatocellular carcinoma (HCC) patients. This retrospective study investigated the significance of multiplication of tumor maximum diameter and number (MDN) as a surgical indicator for Barcelona Clinic Liver Cancer intermediate‐stage HCC.MethodsA total of 49 patients with Barcelona Clinic Liver Cancer intermediate‐stage HCC who underwent curative hepatic resection between 2000 and 2020 were enrolled in this study. Prognostic factors of overall survival and disease‐free survival, including the product of MDN, were analyzed.ResultsPatients with MDN >12 experienced significantly worse prognosis compared with those with MDN ≤12 (p = 0.0395), and 5‐year overall survival rates after hepatic resection were 60.0% and 23.4%, respectively. Furthermore, the disease‐free survival rate of patients with MDN >12 was significantly worse compared with those with MDN ≤12 (p = 0.0049), and all patients with MDN >12 experienced recurrence within 3 years after hepatic resection. In the multivariate analysis, MDN >12 was identified as the only independent prognostic factor of both overall survival and disease‐free survival. In addition, patients with MDN >12 suffered from uncontrollable recurrence by locoregional treatment, such as more than four intrahepatic and extrahepatic recurrences, after hepatic resection.ConclusionsMDN index might be a new surgical indicator for Barcelona Clinic Liver Cancer intermediate‐stage HCC, and influence clinical decision‐making for individual treatment strategies.
Subject
Infectious Diseases,Hepatology
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献