Physicochemical and biological evaluation of a cinnamamide derivative R,S -(2E )-1-(3-hydroxypiperidin-1-yl)-3-phenylprop-2-en-1-one (KM-608) for nervous system disorders-Reference-Cited by-同舟云学术

Physicochemical and biological evaluation of a cinnamamide derivative R,S -(2E )-1-(3-hydroxypiperidin-1-yl)-3-phenylprop-2-en-1-one (KM-608) for nervous system disorders

Published:2017-02-16 Issue:2 Volume:90 Page:244-253
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Gunia-Krzyżak Agnieszka¹^ORCID,Żesławska Ewa²^ORCID,Bareyre Florence M.³⁴,Nitek Wojciech⁵,Waszkielewicz Anna M.¹,Marona Henryk¹

Affiliation:

1. Chair of Organic Chemistry; Department of Bioorganic Chemistry; Faculty of Pharmacy; Jagiellonian University Medical College; Kraków Poland

2. Department of Chemistry; Institute of Biology; Pedagogical University; Kraków Poland

3. Institute of Clinical Neuroimmunology, Hospital and Biomedical Center (BMC); Ludwig-Maximilians University; Munich Germany

4. Munich Cluster of Systems Neurology (SyNergy); Munich Germany

5. Faculty of Chemistry; Jagiellonian University; Kraków Poland

Funder

Uniwersytet Jagielloński Collegium Medicum

European Regional Development Fund through the Innovative Economy Operational Program

Pedagogical University in Krakow

Fundacja na rzecz Nauki Polskiej

Deutsche Forschungsgemeinschaft

Munich Center for Neurosciences (MCN)

Wings for Life

Munich Center for Systems Neurology

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12943/fullpdf

Reference35 articles.

1. Cinnamamide Derivatives for Central and Peripheral Nervous System Disorders-A Review of Structure-Activity Relationships

2. Chemical modification and structure-activity relationship studies of piperine and its analogs: an example of drug development from folk medicine

3. Antiepileptic effect of antiepilepsirine in pentylenetetrazol and amygdala kindled rats

4. Anticonvulsants Containing the N-(3-Aryl-2-propenoyl) amido Pharmacophore

5. Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols

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