Anxiolytic-like effect of 2-(4-((1-phenyl-1H -pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol is mediated through the benzodiazepine and nicotinic pathways

Author:

Brito Adriane F.1,Fajemiroye James O.1,Neri Hiasmin F. S.1,Silva Dayane M.1,Silva Daiany P. B.1,Sanz Germán2,Vaz Boniek G.2,de Carvalho Flávio S.3,Ghedini Paulo C.1,Lião Luciano M.3,Menegatti Ricardo4,Costa Elson A.1ORCID

Affiliation:

1. Department of Pharmacology; ICB; Federal University of Goiás; Goiânia GO Brazil

2. Chemistry Institute; Laboratory of Chromatography and Mass Spectrometry; Federal University of Goiás; Goiânia GO Brazil

3. Chemistry Institute; Federal University of Goias; Goiânia GO Brazil

4. Faculty of Pharmacy; Laboratory of Medicinal Pharmaceutical Chemistry; Federal University of Goiás; Goiânia GO Brazil

Funder

Universidade Federal de Goiás

Fundação de Amparo à Pesquisa do Estado de Goiás

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference43 articles.

1. NIH - National Institute of Mental Health. 2016 Anxiety disorders http://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml

2. CBHSQ - Center for Behavioral Health Statistics and Quality 2015 Behavioral health trends in the United States: Results from the 2014 National Survey on Drug Use and Health http://www.samhsa.gov/data/

3. PhRMA 2014 Medicines in Development for Mental Health http://www.phrma.org/sites/default/files/pdf/2014-mental-health-report.pdf

4. PhRMA 2016 Medicines in Development for Mental Illnesses. 2016 Update http://phrma.org/sites/default/files/pdf/medicines-in-development-report-mental-illnesses.pdf

5. WHO - World Health Organization Regional Office for Europe 2013 RC 63 fact sheet on mental health http://www.euro.who.int/__data/assets/pdf_file/0004/215275/RC63-Fact-sheet-MNH-Eng.pdf

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