Virtual screening, SAR, and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor
Author:
Affiliation:
1. School of Pharmacy and Pharmaceutical Sciences; Cardiff University; Cardiff UK
2. Faculty of Pharmacy; Zagazig University; Zagazig Egypt
3. Cardiff China Medical Research Collaborative; Cardiff University; Cardiff UK
Publisher
Wiley
Subject
Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12936/fullpdf
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1. Hallmarks of Cancer: The Next Generation
2. The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update
3. The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
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5. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
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