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Identification and functional characterization of a novelF5mutation (Ala512Val, FVBonn) associated with activated protein C resistance

  • Published:2016-06-13 Issue:7 Volume:14 Page:1353-1363
  • ISSN:1538-7933
  • Container-title:Journal of Thrombosis and Haemostasis
  • language:en
  • Short-container-title:J Thromb Haemost

Author:

Pezeshkpoor B.1,Castoldi E.2,Mahler A.3,Hanel D.3,Müller J.1,Hamedani N. S.1,Biswas A.1,Oldenburg J.1,Pavlova A.1

Affiliation:

1. Institute of Experimental Hematology and Transfusion Medicine; University Clinic Bonn; Bonn Germany

2. Department of Biochemistry; Cardiovascular Research Institute Maastricht (CARIM); Maastricht University; Maastricht the Netherlands

3. Synlab MVZ; Stuttgart Germany

Publisher

Wiley

Subject

Hematology

Reference45 articles.

1. Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders;Kane;Blood,1988

2. Thrombin-catalyzed activation of human coagulation factor V;Suzuki;J Biol Chem,1982

3. Activation of human factor V by factor Xa and thrombin;Monkovic;Biochemistry,1990

4. The role of phospholipids and factor Va in the prothrombinase complex;Rosing;J Biol Chem,1980

5. Advances in understanding the bleeding diathesis in factor V deficiency;Duckers;Br J Haematol,2009
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