1. Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando; Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria la Princesa; Madrid Spain
2. Department of Anaesthesiology, Reanimation and Pain Treatment; Hospital Clínico San Carlos; Madrid Spain
3. Pharmaceutical Technology, Facultad de Farmacia; Universidad Complutense de Madrid; Spain
4. Division of Biopharmaceutics Evaluation, Bureau of Pharmaceutical Sciences; Therapeutic Products Directorate, Health Canada; Ottawa Canada
5. Service on Pharmacokinetics and Generics, Division of Pharmacology and Clinical Evaluation, Department of Human Use Medicines; Spanish Agency for Medicines and Health Care Products; Madrid Spain