Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions

Author:

Stopfer Peter1ORCID,Giessmann Thomas1,Hohl Kathrin1,Hutzel Sabine1,Schmidt Sven1,Gansser Dietmar1,Ishiguro Naoki2,Taub Mitchell E.3,Sharma Ashish1,Ebner Thomas1,Müller Fabian14

Affiliation:

1. Boehringer Ingelheim Pharma GmbH & Co. KG; Birkendorfer Str. 65 88397 Biberach an der Riss Germany

2. Kobe Pharma Research Institute; Nippon Boehringer Ingelheim Co. Ltd.; Chuo-ku Kobe City Japan

3. Boehringer Ingelheim Pharmaceuticals Inc.; 900 Ridgebury Road Ridgefield CT 06877 USA

4. Friedrich-Alexander-Universität Erlangen-Nürnberg; Institute of Experimental and Clinical Pharmacology and Toxicology; Fahrstr. 17 91054 Erlangen Germany

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference24 articles.

1. Transporters and drug-drug interactions: important determinants of drug disposition and effects;König;Pharmacol Rev,2013

2. Membrane transporters in drug development;Giacomini;Nat Rev Drug Discov,2010

3. Transporter-mediated drug uptake and efflux: important determinants of adverse drug reactions;Zolk;Clin Pharmacol Ther,2011

4. Emerging transporters of clinical importance: an update from the International Transporter Consortium;Hillgren;Clin Pharmacol Ther,2013

5. US-FDA Guidance for industry: clinical drug interaction studies - study design, data analysis, and clinical implications (draft guidance) 2017 https://www.fda.gov/downloads/drugs/guidances/ucm292362.pdf

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