Doxycycline pharmacokinetics and tissue depletion in striped catfish (Pagasianodon hypophthalmus) after oral administration

Author:

Vinh Pham Quang1,Thinh Nguyen Quoc1ORCID,Devreese Mathias2ORCID,Croubels Siska2,Oanh Dang Thi Hoang1,Dalsgaard Anders3,Maita Masashi4,Phu Tran Minh1

Affiliation:

1. College of Aquaculture and Fisheries Can Tho University Can Tho Vietnam

2. Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine Ghent University Merelbeke Belgium

3. Faculty of Health and Medical Sciences University of Copenhagen Frederiksberg C Denmark

4. Laboratory of Fish Health Management Tokyo University of Marine Science and Technology Minato Tokyo Japan

Abstract

AbstractThe pharmacokinetics and residue depletion of doxycycline (DOX) in striped catfish (Pagasianodon hypophthalmus) after oral dosage were investigated. The pharmacokinetic experiment was conducted in an aquarium, while the experiment of residue depletion was performed in both an aquarium and earth ponds. Medicated feed was administered orally using the gavage method at a dosage of 20 mg/kg body weight. Blood, liver, and kidney from medicated fish samples were collected. In the depletion experiments, fish were fed medicated feed for five consecutive days at a dosage of 20 mg/kg body weight, with samples collected during and after medication. The concentrations of DOX were quantified using an LC–MS/MS system. The pharmacokinetics parameters of DOX in striped catfish included the absorption rate constant (ka), absorption half‐life (T1/2abs), maximal plasma concentration (Cmax), time to maximal plasma concentration (Tmax), and area under the plasma concentration–time curve from time 0 to 96 h (AUC0–96 h) which were 0.12 h−1, 5.68 h, 1123.45 ng/mL, 8.19 h, and 25,018 ng/mL/h, respectively. Residue depletion results indicated that the withdrawal times of DOX in muscle (with skin) from fish kept in the aquarium were slightly longer than that in fish raised in earth ponds, corresponding to 194 degree‐days compared with 150 degree‐days. In conclusion, administration of DOX at the dosage of 20 mg/kg body weight can be used for treatment of bacterial infections in striped catfish, and a withdrawal time of 5 days at 29.4°C will ensure consumer food safety due to the rapid depletion of DOX from muscle and skin.

Publisher

Wiley

Reference34 articles.

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3. The Use of Drugs, Chemicals, Herbs, and Herbal Extract Products in Grow-out Farms of Snakehead (Channa striata) and Pangasius Catfish (Pangasianodon hypophthalmus) in the Mekong Delta, Vietnam

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5. EMA European Medicines Agency (2015). European public MRL assessment report (EPMAR) Doxycycline (all food producing species).https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjjstPN76n5AhVhm1YBHbURAm8QFnoECAwQAQ&url=https%3A%2F%2Fwww.ema.europa.eu%2Fdocuments%2Fmrl‐report%2Fdoxycycline‐all‐food‐producing‐species‐european‐public‐maximum‐residue‐limit‐assessment‐report‐epmar_en.pdf&usg=AOvVaw01at2hRLFJVLTpVCVGogL8.

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