Manufacturing‐dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development

Author:

Steeghs Neeltje1,Hansen Aaron R.2,Hanna Glenn J.34,Garralda Elena5,Park Haeseong6,Strauss James7,Adam Michael8,Campbell Gossett8,Carver Jennifer8,Easton Rachael8,Mays Katherine8,Skrdla Peter8,Struemper Herbert9,Washburn Michael L.8ORCID,Matheny Christopher8,Piha‐Paul Sarina A.10

Affiliation:

1. Netherlands Cancer Institute Amsterdam The Netherlands

2. Princess Margaret Cancer Centre Toronto Ontario Canada

3. Northwest Medical Specialists Tacoma Washington State USA

4. Dana‐Farber Cancer Institute Boston Massachusetts USA

5. Vall d'Hebron Institute of Oncology (VHIO) Hospital Universitari Vall d'Hebron Barcelona Spain

6. Washington University St Louis Missouri USA

7. Mary Crowley Cancer Research Center Dallas Texas USA

8. GlaxoSmithKline Collegeville Pennsylvania USA

9. GlaxoSmithKline Durham North Carolina USA

10. University of Texas MD Anderson Cancer Center Houston Texas USA

Funder

GlaxoSmithKline

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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