Genetic Epidemiology of Mitochondrial Pathogenic Variants Causing Nonsyndromic Hearing Loss in a Large Cohort of South Indian Hearing Impaired Individuals

Author:

Subathra Mahalingam1,Ramesh Arabandi1,Selvakumari Mathiyalagan1,Karthikeyen N. P.2,Srisailapathy C. R. Srikumari1

Affiliation:

1. Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences; University of Madras; Taramani Campus Chennai India

2. DOAST (Doctrine Oriented Art of Symbiotic Treatment) Hearing Care Center and Integrated Therapy Center for Autism; Anna Nagar West Chennai India

Funder

Senior Research Fellowship of Indian Council of Medical Research and Research Associateship of Department of Biotechnology

Senior Research Fellowship of Indian Council of Medical Research

University Grants Commission

Special Assistance Programme, DST-FIST II and UPE

University Industry Community Interaction Centre

University of Madras

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Reference121 articles.

1. Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A->G mitochondrial mutation;Abe;Am J Med Genet,2001

2. The molecular dissection of mtDNAhaplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool;Achilli;Am J Hum Genet,2004

3. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA;Andrews;Nat Genet,1999

4. Prevalence of theA1555G MTDNA mutation in sporadic hearing-impaired patients without known history of aminoglycoside treatment;Angulo;Acta Otorrinolarinol Esp,2011

5. Relative frequencies of themitochondrial A1555G and 961 del T mutations in the 12SrRNA gene in a large sample of deaf probands from the United States;Arnos;Am J Hum Genet,2003

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