Melanoma secretion of transforming growth factor‐β2 leads to loss of epidermal AMBRA1 threatening epidermal integrity and facilitating tumour ulceration

Author:

Cosgarea I.12,McConnell A.T.1,Ewen T.1,Tang D.1,Hill D.S.13,Anagnostou M.1,Elias M.1,Ellis R.A.12ORCID,Murray A.1,Spender L.C.4,Giglio P.5,Gagliardi M.6,Greenwood A.1,Piacentini M.57,Inman G.J.8ORCID,Fimia G.M.79,Corazzari M.6,Armstrong J.L.13ORCID,Lovat P.E.12ORCID

Affiliation:

1. Translation and Clinical Research Institute The Medical School Newcastle University Newcastle UK

2. AMLo Biosciences Ltd The Biosphere Newcastle upon Tyne UK

3. Faculty of Health Sciences and Wellbeing University of Sunderland Sunderland UK

4. Jacqui Wood Cancer Centre & Nine Wells Hospital and Medical School University of Dundee Dundee UK

5. Department of Biology University of Rome ‘Tor Vergata’ Rome Italy

6. Department Health Sciences, and Centre for Translational Research on Autoimmune and Allergic Disease (CAAD) University of Piemonte Orientale Novara Italy

7. Department of Epidemiology Preclinical Research, and Advanced Diagnostics National Institute for Infectious Diseases ‘L. Spallanzani’ IRCCS Rome Italy

8. CRUK Beatson Institute and Institute of Cancer Sciences University of Glasgow Glasgow UK

9. Department of Molecular Medicine Sapienza University of Rome Rome Italy

Funder

Cancer Research UK

British Skin Foundation

Worldwide Cancer Research

Publisher

Wiley

Subject

Dermatology

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