KEYNOTE-025: Phase 1b study of pembrolizumab in Japanese patients with previously treated programmed death ligand 1-positive advanced non-small-cell lung cancer

Author:

Nishio Makoto1ORCID,Takahashi Toshiaki2,Yoshioka Hiroshige3,Nakagawa Kazuhiko4,Fukuhara Tatsuro5,Yamada Kazuhiko6,Ichiki Masao7,Tanaka Hiroshi8,Seto Takashi9ORCID,Sakai Hiroshi10,Kasahara Kazuo11,Satouchi Miyako12,Han Shi Rong13,Noguchi Kazuo13,Shimamoto Takashi13,Kato Terufumi14

Affiliation:

1. Department of Thoracic Medical Oncology; The Cancer Institute Hospital of Japanese Foundation for Cancer Research; Tokyo Japan

2. Division of Thoracic Oncology; Shizuoka Cancer Center; Suntogun Japan

3. Department of Respiratory Medicine; Kurashiki Central Hospital; Kurashiki Japan

4. Department of Medical Oncology; Faculty of Medicine; Kindai University; Osaka-Sayama Japan

5. Department of Respiratory Medicine; Miyagi Cancer Center; Natori Japan

6. Department of Internal Medicine; Division of Respirology, Neurology, and Rheumatology; Kurume University; Kurume Japan

7. Respiratory Medicine; Kyushu Medical Center; Fukuoka Japan

8. Department of Internal Medicine (Pulmonology); Niigata Cancer Center Hospital; Niigata Japan

9. Department of Thoracic Oncology; National Kyushu Cancer Center; Fukuoka Japan

10. Thoracic Oncology; Saitama Cancer Center; Saitama Japan

11. Respiratory Medicine; Kanazawa University Hospital; Kanazawa Japan

12. Department of Thoracic Oncology; Hyogo Cancer Center; Akashi Japan

13. Oncology Science Unit; MSD K.K.; Tokyo Japan

14. Department of Respiratory Medicine; Kanagawa Cardiovascular and Respiratory Center; Yokohama Japan

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference22 articles.

1. Center for Cancer Control and Information Services, National Cancer Center Cancer statistics in Japan - 2015 2016 https://ganjoho.jp/en/professional/statistics/brochure/2015_en.html

2. Treatment paradigms for patients with metastatic non-small-cell lung cancer: first-, second-, and third-line;Leighl;Curr Oncol,2012

3. Pembrolizumab as first-line therapy for metastatic non-small-cell lung cancer;Reck;Immunotherapy,2018

4. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial;Herbst;Lancet,2016

5. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer;Reck;N Engl J Med,2016

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