Anti-arthritic activity of 11-O-(4′-O-methyl galloyl)-bergenin and Crassula capitella extract in rats

Author:

El-Hawary Seham S1,Mohammed Rabab2,Abouzid Sameh2,Ali Zeinab Y3,Elwekeel Ahlam2

Affiliation:

1. Faculty of Pharmacy, Cairo University, Cairo, Egypt

2. Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

3. Biochemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt

Abstract

Abstract Objectives Isolation and identification of phytochemicals of Crassula capitella (Thunberg), evaluation of the anti-arthritic potential of the extract and the major isolated compound; 11-O-(4′-O-methyl galloyl)-bergenin and underlying their mechanism on rat model of rheumatoid arthritis (RA). Methods Different fractions were subjected to column chromatography giving fourteen compound identified by mass and NMR spectroscopic techniques. RA was induced by intraplantar injection of complete Freund's adjuvant into the right hind paw of rats. Influence of tested samples in comparable to methotrexate on paw oedema, body weight gain, serum diagnostic markers, cartilage and bone degeneration enzymes, pro-inflammatory mediators and oxidative stress biomarkers in arthritic rats. Key findings Fourteen phenolic compounds were isolated and identified for the first time from C. capitella. The major compound identified as 11-O-(4′-O-methyl galloyl)-bergenin. Treatment of arthritic rats with extract or 11-O-(4′-O-methyl galloyl)-bergenin with the tested doses can reduce the progression and severity of RA. Conclusion Crassula capitella is a new natural and abundant source for 11-O-(4′-O-methyl galloyl)-bergenin for resolving chronic inflammatory diseases as RA through antioxidant, anti-inflammatory and membrane stabilizing mechanism.

Funder

Beni-Suef University

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3