Blocking the phosphatidylinositol 3-kinase pathway inhibits neuregulin-1-mediated rescue of neurotoxicity induced by Aβ1–42

Author:

Baik Tai-Kyoung1,Kim Young-Jung1,Kang Se-Mi1,Song Dae-Yong1,Min Sun Seek2,Woo Ran-Sook1

Affiliation:

1. Department of Anatomy and Neuroscience, College of Medicine, Eulji University, Daejeon, Korea

2. Department of Physiology and Biophysics, College of Medicine, Eulji University, Daejeon, Korea

Abstract

Abstract Objectives Neuregulin-1 (NRG1) has an important role in both the development and the plasticity of the brain as well as neuroprotective properties. In this study, we investigated the downstream pathways of NRG1 signalling and their role in the prevention of Aβ1–42-induced neurotoxicity. Methods Lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) generation, superoxide dismutase (SOD) activity and TUNEL staining were assayed to examine the neuroprotective properties in primary rat cortical neurons. Key findings The inhibition of PI3K/Akt activation abolished the ability of NRG1 to prevent Aβ1–42-induced LDH release and increased TUNEL-positive cell count and reactive oxygen species accumulation in primary cortical neurons. Conclusions Our results demonstrate that NRG1 signalling exerts a neuroprotective effect against Aβ1–42-induced neurotoxicity via activation of the PI3K/Akt pathway. Furthermore, this suggests that NRG1 has neuroprotective potential for the treatment of AD.

Funder

Institute for Information & communications Technology Promotion

Korea government

Ministry of Education, Science and Technology

National Research Foundation of Korea

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3