The multifunctional peptide DN‐9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ‐ and κ‐opioid receptors-Reference-Cited by-同舟云学术

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The multifunctional peptide DN‐9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ‐ and κ‐opioid receptors

Published:2019-12-23 Issue:1 Volume:177 Page:93-109
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Xu Biao¹,Zhang Mengna¹,Shi Xuerui¹,Zhang Run¹,Chen Dan¹,Chen Yong²,Wang Zilong¹,Qiu Yu³,Zhang Ting¹,Xu Kangtai¹,Zhang Xiaoyu¹^ORCID,Liedtke Wolfgang²,Wang Rui¹^ORCID,Fang Quan¹^ORCID

Affiliation:

1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences Lanzhou University Lanzhou China

2. Department of Neurology Duke University School of Medicine Durham North Carolina

3. Department of Pharmacology and Chemical Biology, Institute of Medical Sciences Shanghai Jiao Tong University School of Medicine Shanghai China

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.14848

Reference60 articles.

1. Will peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential?

2. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors

3. Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

4. The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain

5. The Peripheral Versus Central Antinociception of a Novel Opioid Agonist: Acute Inflammatory Pain in Rats

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1. Intrathecal administration of MCRT produced potent antinociception in chronic inflammatory pain models via μ-δ heterodimer with limited side effects;Biomedicine & Pharmacotherapy;2024-10

2. Conorphin-66 produces peripherally restricted antinociception via the kappa-opioid receptor with limited side effects;Neuropharmacology;2024-09

3. Peptide-derived ligands for the discovery of safer opioid analgesics;Drug Discovery Today;2024-05

4. Structure–Activity Relationships of a Novel Cyclic Hexapeptide That Exhibits Multifunctional Opioid Agonism and Produces Potent Antinociceptive Activity;Journal of Medicinal Chemistry;2023-12-20

5. All-Hydrocarbon Stapled Peptide Multifunctional Agonists at Opioid and Neuropeptide FF Receptors: Highly Potent, Long-Lasting Brain Permeant Analgesics with Diminished Side Effects;Journal of Medicinal Chemistry;2023-12-14

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