Pharmacology of AMG 181, a human anti-α4β7antibody that specifically alters trafficking of gut-homing T cells

Author:

Pan WJ1,Hsu H2,Rees WA3,Lear SP3,Lee F2,Foltz IN4,Rathanaswami P4,Manchulenko K4,Chan BM4,Zhang M2,Xia XZ2,Patel SK1,Prince PJ1,Doherty DR1,Sheckler CM1,Reynhardt KO3,Krill CD3,Harder BJ3,Wisler JA5,Brandvig JL6,Lynch JL7,Anderson AA8,Wienkers LC1,Borie DC9

Affiliation:

1. Department of Pharmacokinetics and Drug Metabolism; Amgen Inc.; Seattle; WA; USA

2. Department of Inflammation Discovery Research; Amgen Inc.; Thousand Oaks; CA; USA

3. Department of Medical Sciences; Amgen Inc.; Seattle; WA; USA

4. Department of Biologic Discovery; Amgen Inc.; Burnaby; BC; Canada

5. Department of Comparative Biology and Safety Sciences; Amgen Inc.; Thousand Oaks; CA; USA

6. Department of Comparative Biology and Safety Sciences; Amgen Inc.; Seattle; WA; USA

7. Department of Preclinical Services; Charles River Laboratories International, Inc.; Reno; NV; USA

8. Department of Medical Sciences; Amgen Inc.; Thousand Oaks; CA; USA

9. Department of Global Development; Amgen Inc.; Thousand Oaks; CA; USA

Publisher

Wiley

Subject

Pharmacology

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