The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers

Author:

Bain C. R.1,Draxler D. F.2,Taylor R.3,Wallace S.1,Gouldthorpe O.1,Corcoran T. B.4,Myles P. S.1,L. Medcalf R.2,Bozaoglu K.5

Affiliation:

1. Department of Anaesthesia and Peri -operative Medicine; The Alfred Hospital and Monash University; Melbourne Vic. Australia

2. Molecular Neurotrauma and Haemostasis laboratory; Australian Centre for Blood Diseases and Monash University; Melbourne Vic. Australia

3. Genomics and Systems Biology Laboratory; Baker IDI Heart and Diabetes Institute Victoria; Melbourne Vic. Australia

4. Department of Anaesthesia and Pain Medicine Royal Perth Hospital and; University of Western Australia; Perth WA Australia

5. Bruce Lefroy Centre for Genetic Health Research; Murdoch Children's Research Institute and Department of Paediatrics; University of Melbourne; Melbourne Vic. Australia

Funder

Australian and New Zealand College of Anaesthetists

National Health and Medical Research Council

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine

Reference33 articles.

1. Consensus guidelines for the management of postoperative nausea and vomiting;Gan;Anesthesia and Analgesia,2014

2. The perioperative immune response;O'Dwyer;Current Opinion in Critical Care,2015

3. The ups and downs of glucocorticoid physiology. Permissive and suppressive effects revisited;Munck;Molecular and Cellular Endocrinology,1992

4. Glucocorticoids enhance the in vivo migratory response of human monocytes;Yeager;Brain, Behavior, and Immunity,2016

5. Glucocorticoids and the Th1/Th2 balance;Elenkov;Annals of the New York Academy of Sciences,2004

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