MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjögren's syndrome

Author:

Sung HH1,Castro I1,González S2,Aguilera S3,Smorodinsky NI4,Quest AFG15,Bahamondes V1,Alliende C1,Cortés J1,Molina C2,Urzúa U1,Barrera M-J1,Hermoso M1,Herrera L1,Leyton C1,González M-J1

Affiliation:

1. Instituto de Ciencias Biomédicas; Facultad de Medicina; Universidad de Chile; Santiago Chile

2. Facultad de Odontología; Universidad Mayor; Santiago Chile

3. Departamento de Reumatología; Clínica INDISA; Santiago Chile

4. The Alec and Myra Marmot Hybridoma Unit; the Department of Cell Research and Immunology; George S. Wise Faculty of Life Sciences; Tel Aviv University; Tel Aviv Israel

5. Center for Molecular Studies of the Cell (CEMC); and Advanced Center for Chronic Diseases (ACCDiS); ICBM; Facultad de Medicina; Universidad de Chile; Santiago Chile

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

Wiley

Subject

General Dentistry,Otorhinolaryngology

Reference42 articles.

1. Salivary mucins: protective functions in relation to their diversity;Amerongen;Glycobiology,1995

2. Changes in Rab3D expression and distribution in the acini of Sjogren's syndrome patients are associated with loss of cell polarity and secretory dysfunction;Bahamondes;Arthritis Rheum,2011

3. Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren's syndrome patients is linked to ectopic mucin secretion;Barrera;J Autoimmun,2012

4. Sjogren's syndrome and the epithelial target: a comprehensive review;Barrera;J Autoimmun,2013

5. Salivary mucins induce a TLR4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren's syndrome?;Barrera;Rheumatology (Oxford),2014

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