2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels

Author:

Yeramian Andree1,Vea Alvar2,Benítez Sandra1,Ribera Joan3,Domingo Mónica1,Santacana Maria1,Martinez Montserrat4,Maiques Oscar1,Valls Joan4,Dolcet Xavier1,Vilella Ramón5,Cabiscol Elisa6,Matias-Guiu Xavier1,Marti Rosa M.2

Affiliation:

1. Pathology Group; Department of Pathology and Molecular Genetics; Hospital Universitari Arnau de Vilanova HUAV; IRBLleida; University of Lleida; Lleida Spain

2. Department of Dermatology; Hospital Universitari Arnau de Vilanova; IRB-Lleida; University of Lleida; Lleida Spain

3. Developmental and Oncogenic Signalling Group; IRBLleida; Lleida Spain

4. Biostatistics Unit; Hospital Universitari Arnau de Vilanova; IRB-Lleida; University of Lleida; Lleida Spain

5. Department of Immunology; Hospital Clinic; Barcelona Spain

6. Departament de Ciencies Mediques basiques; IRBlleida; University of Lleida; Lleida Spain

Funder

Lliga contra el càncer de les comarques de Lleida

Instituto de Salud Carlos III

Fundació la Marató de TV3

Generalitat de Catalunya

Albert Einstein Cancer Center

Xarxa Catalana de Bancs de Tumours

Tumour Banc Platform of RTICC

Novartis

Publisher

Wiley

Subject

Dermatology,General Biochemistry, Genetics and Molecular Biology,Oncology

Reference76 articles.

1. Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines;Adjei;Clin. Cancer Res.,2001

2. The roles of therapy-induced autophagy and necrosis in cancer treatment;Amaravadi;Clin. Cancer Res.,2007

3. Absence of progesterone receptor associated with secondary breast cancer in postmenopausal women;Balleine;Br. J. Cancer,1999

4. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome;Beere;Nat. Cell Biol.,2000

5. Combination of Vorinostat and caspase-8 inhibition exhibits high anti-tumoral activity on endometrial cancer cells;Bergadà;Mol. Oncol.,2013

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