Assessment of current practices and perceived effectiveness of injectable polynucleotide for enlarged facial pores among cosmetic physicians: A survey‐based evaluation

Author:

Lee Dagyeong1ORCID,Choi Hosung2,Yoo Kyounghun3,Park Young Jin4,Park Hyun Jun5,Oh Seung Min6ORCID,Ji Gun Hyon7,Rah Gong Chan8,Shin Dong Wook910

Affiliation:

1. Department of Family Medicine Hallym University Dongtan Sacred Heart Hospital Hwaseong Republic of Korea

2. Piena Aesthetic Clinic Seoul Republic of Korea

3. Lumi Clinic Seoul Republic of Korea

4. Obliv Clinic Incheon Republic of Korea

5. Maylin Clinic Seoul Republic of Korea

6. Gangnam ON Clinic Seoul Republic of Korea

7. Yonseidongan Clinic Seoul Republic of Korea

8. Robbin Clinic Seoul Republic of Korea

9. Department of Family Medicine/Supportive Care Center Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea

10. Department of Clinical Research Design & Evaluation Samsung Advanced Institute for Health Science & Technology (SAIHST) Sungkyunkwan University Seoul Republic of Korea

Abstract

AbstractBackgroundPolynucleotides stimulate collagen formation and are used clinically to enhance elasticity. In this study, we investigated current practices and perceived effectiveness of polynucleotide injection treatment for enlarged facial pores among cosmetic physicians.Materials and MethodsA survey was developed to investigate clinicians’ use and effectiveness of polynucleotides in the treatment of enlarged facial pores. This survey was distributed to clinicians at the Korean Aesthetic Surgery & Laser Society Autumn Symposium.ResultsA total of 407 physicians who used polynucleotides for enlarged facial pores were enrolled in the survey. Polynucleotides were used by 75.7%, 87.7%, and 72.2% of physicians for enlarged facial pores caused by excessive sebum production, reduced elasticity, and acne, respectively. Among those users, 81.4%, 83.8%, and 76.8% in those same categories, respectively, responded that polynucleotides were “very effective” or “effective.” Furthermore, most clinicians combined polynucleotides with microneedle radiofrequency as energy‐based devices and with botulinum toxin as injection therapy.ConclusionThis study highlights the widespread use and perceived efficacy of polynucleotide injection among cosmetic physicians in the Republic of Korea for enlarged facial pores due to excessive sebum production, reduced elasticity, and acne. Positive feedback from practitioners supports the benefits of using polynucleotides in enlarged facial pore treatment.

Publisher

Wiley

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4. Pharmacological activity and clinical use of PDRN;Squadrito F;Front Pharmacol,2017

5. Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis;Bitto A;J Clin Periodontol,2013

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