Gut microbiota in brain tumors: An emerging crucial player

Author:

Lin Ben12345,Ye Zhen12345,Ye Zhao12345,Wang Meng6,Cao Zhan7,Gao Renyuan7,Zhang Yichao12345ORCID

Affiliation:

1. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University Shanghai China

2. National Center for Neurological Disorders Shanghai China

3. Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration Shanghai China

4. Neurosurgical Institute of Fudan University Shanghai China

5. Shanghai Clinical Medical Center of Neurosurgery Shanghai China

6. Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College Fudan University Shanghai China

7. Department of General Surgery, Shanghai Tenth People's Hospital, School of Medicine Tongji University Shanghai China

Abstract

AbstractIn recent decades, various roles of the gut microbiota in physiological and pathological conditions have been uncovered. Among the many interacting pathways between the host and gut flora, the gut–brain axis has drawn increasing attention and is generally considered a promising way to understand and treat brain tumors, one of the most lethal neoplasms. In this narrative review, we aimed to unveil and dissect the sophisticated mechanisms by which the gut‐brain axis exerts its influence on brain tumors. Furthermore, we summarized the latest research regarding the gastrointestinal microbial landscape and the effect of gut–brain axis malfunction on different brain tumors. Finally, we outlined the ongoing developing approaches of microbial manipulation and their corresponding research related to neuro‐malignancies. Collectively, we recapitulated the advances in gut microbial alterations along with their potential interactive mechanisms in brain tumors and encouraged increased efforts in this area.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology

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