Affiliation:
1. Department of Clinical Biochemistry Department of Basic Medical Sciences College of Medicine Shaqra University Dawadmi Saudi Arabia
2. Molecular Genetics and Enzymology Department Human Genetics and genome research institute National Research Center 33 El Bohouth St. (former El Tahrir St.) Dokki Cairo Egypt
3. Departments of Dermatology College of Medicine Shaqra University Dawadmi Saudi Arabia
4. Department of Microbiology and Immunology Faculty of medicine and health sciences Sana'a University Sana'a Yemen
5. Department of Dermatology Venereology, and Sexology Faculty of Medicine Suez Canal University Ismailia Egypt
Abstract
AbstractBackground and aimsPsoriasis is a chronic, non‐contagious autoimmune condition marked by dry, itchy,erythematous and scaly plaques. From modest, localized plaques to total body coverage, the severity of psoriasis varies. Plaque, guttate, inverted, pustular, and erythrodermic psoriasis are the five primary kinds. About 90% of cases are of plaque psoriasis, commonly known as psoriasis vulgaris. Study aims to determine the impact of an rs2228570 (FokI) variant and an rs11568820 (CDX2) variant on serum vitamin D levels (SVD) in patients with psoriasis, and the correlation between the two variants and disease severity.MethodsA case‐control study consisting of 95 psoriasis vulgaris patients and 84 healthy controls. The clinical investigation, molecular genetics analysis, and biochemical analysis were done for both groups.ResultsSVD levels were significantly decreased in psoriasis patients group. FokI genotypes analysis, we found no significant variance between groups. CDX2 G/G genotype is more prevalent in patients than controls. Moderate psoriasis vulgaris patients with CDX2 G/G genotypes have higher SVD levels than CDX2 G/A, and CDX2 A/A p = 0.003.ConclusionThe study found a difference in vitamin D levels between patients and healthy subjects, as well as a difference in vitamin D levels with different FoKI and CDX2 genotypes.